AG Scientific
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AG Scientific è specializzata in metaboliti secondari derivati dalla fermentazione. La maggior parte dei prodotti è costituita da antibiotici per la selezione genica, ma il catalogo comprende anche reagenti antimicrobici, antimicotici, antitumorali, antivirali, antiparassitari e immunosoppressori.
Antibiotici:
AG Scientific, Inc. ha sviluppato una serie di agenti di screening antibiotico, tra cui Blasticidin S, G-418, Puromicina, Gentamicina, Kanamicina, Ampicillina, Streptomicina, Carbenicillina.
Più recentemente, AG Scientific ha stretto una partnership con clienti farmaceutici che utilizzano la tecnologia CRISPR.
Antitumorale:
Il catalogo comprende metaboliti secondari nel campo del cancro come rapamicina, FK-506, ciclosporina A.
Sito web: www.agscientific.com
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Aristolochic Acid
Aristolochic acid, inherent in the Aristolochiaceae plant family, stands as a subject of profound interest in immunology, cell biology, and molecular biology. This nitrophenanthrene carboxylic acid, encompassing variants such as aristolochic acid I and II, possesses a distinctive chemical structure that intertwines with intricate biological processes.
In immunology, research delves into the compound's potential immunomodulatory effects, shedding light on its role in endosomal acidification and immune cell activation. Concurrently, in cell biology, aristolochic acid's impact on intracellular pH dynamics, enzymatic activities, and membrane transport contributes to the understanding of cellular homeostasis.
At the molecular level, aristolochic acid’s unique structure influences nucleic acids and proteins, unveiling its significance in DNA replication, transcription, and translation. Scientific endeavors, guided by meticulous analytical techniques, aim to unravel the molecular mechanisms underpinning its actions.
Recognizing the dual nature of aristolochic acid, from historical applications in traditional medicine to contemporary health concerns, this article navigates through its complexities. The synthesis of immunological, cellular, and molecular perspectives underscores the compound’s pivotal role in the intricate landscape of biological research.