Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Chondrex


Chondrex, Inc. produce prodotti per la ricerca pre-clinica sulle malattie autoimmuni e infiammatorie: reagenti per indurre modelli sperimentali di artrite, asma allergica, colite, sepsi e nefrite, nonché prodotti (anticorpi, ELISA e altri saggi) per analizzare questi modelli e qualsiasi trattamento applicato ad essi. Con oltre 20 anni di esperienza nella purificazione del collagene per il modello di artrite indotta da collagene, siamo anche esperti in tutto ciò che riguarda il collagene. Offriamo molte specie e tipi diversi di collagene purificato per applicazioni in vivo e in vitro, nonché kit di analisi per quantificare i livelli di collagene in campioni di tessuti e colture cellulari. Sito web: www.chondrex.com

Human collagen

The vast family of products of the COL gene (collagens) is composed of several types of chains, interstitial collagens forming fibrils (types I, II, III and V) and basal membrane collagens (type IV). Each type of collagen has several isoforms. Collagens are fibrous extracellular matrix proteins with high tensile strength and are the main components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and often show lateral self-association to form complex connective tissues.

Type I collagen is the main structural component of the extracellular matrix (ECM) found in connective tissue and internal organs, but is most common in the dermis, tendons and bones. It is a 300 kDa molecule composed of two alpha1 chains and an alpha2 chain which spontaneously forms a triple helix scaffold at neutral pH and 37 ° C. This phenomenon can be exploited to promote cellular attachment, growth, differentiation , migration and tissue morphogenesis during development.