bioWORLD
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BioWorld fornisce una varietà di prodotti e servizi per le industrie delle scienze della vita e delle biotecnologie. Forniamo strumenti molecolari di alta qualità, reagenti biologici e forniture di laboratorio per laboratori di analisi, istituzioni educative e di ricerca in tutto il mondo. BioWorld si concentra sui reagenti di bio-affinità per la purificazione delle proteine e la ricerca proteomica. È disponibile un'ampia gamma di proteine ricombinanti e peptidi sintetici.
Sito web: www.bio-world.com |
![Polygonatum cyrtonema Lectin (PCL)](https://www.clinisciences.com/it/upload/pcl-lectin-z9eagy.png)
Polygonatum cyrtonema Lectin (PCL)
Polygonatum cyrtonema (PCL) lectin is a mannose/sialic acid-binding lectin that displays significant inhibitory and cytotoxic activity toward cancer cells. Moreover, the underlying molecular mechanisms of apoptosis and autophagy are also demonstrated and our results suggest that it would be worthwhile to explore the wonderland of plant lectins in regard to cancer therapeutics. PCL was shown to markedly inhibit the growth of human melanoma A375 cells. It was also found to simultaneously induce A375 cell apoptosis and autophagy. The mechanism of apoptosis following treatment with PCL involves regulation of the Bax, Bcl-xL and Bcl-2 proteins, which then cause collapse of the mitochondrial membrane potential. PCL also abrogates the glutathione antioxidant system and induces mitochondria to generate massive ROS accumulation. PCL was additionally found to induce human melanoma A375 cell apoptosis, as evidenced by morphological and ultrastructural changes.
Risultati della ricerca : 2 prodotto(i) trovato(i)
Limita la ricerca :
RUOCE / IVD
- Lectins
- plant 2
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