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Sugar-based detergents, such as Octyl Glucoside, are valued for their mild solubilizing properties. This class of non-ionic detergents is chosen for applications where maintaining the native conformation of membrane proteins is crucial. Octyl Glucoside, for instance, is known for its ability to solubilize membrane proteins without significant denaturation. These detergents work by disrupting hydrophobic interactions in the lipid bilayer, allowing for the extraction of membrane proteins while preserving their structure.