Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare
 
> Anisomycin [22862-76-6]

Anisomycin [22862-76-6]

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Cat# 10-2056-50mg

Size : 50mg

Marca : Focus Biomolecules

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Anisomycin | Anoikis sensitizer

CAS:
22862-76-6
Catalog Number:
10-2056
Activity:
Anoikis sensitizer
Chemical Name:
(2R,3S,4S)-4-Hydroxy-2-)4-methoxybenzyl)pyrrolidin-3-yl acetate
Molecular Weight:
265.31
Molecular Formula:
C14H19NO4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

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10 mg$35.00
50 mg$120.00
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Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable.

References/Citations:

1) Hazzalin et al. (1998), Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos and jun Induction; Mol. Cell. Bio., 8 1844
2) Mawji et al. (2007), A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis; Cancer Res., 67 8307

CAS:
22862-76-6
Catalog Number:
10-2056
Activity:
Anoikis sensitizer
Chemical Name:
(2R,3S,4S)-4-Hydroxy-2-)4-methoxybenzyl)pyrrolidin-3-yl acetate
Molecular Weight:
265.31
Molecular Formula:
C14H19NO4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable.

References/Citations:

1) Hazzalin et al. (1998), Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos and jun Induction; Mol. Cell. Bio., 8 1844
2) Mawji et al. (2007), A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis; Cancer Res., 67 8307