Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Anti-Chapsyn-110/PSD-93 Antibody FL550 Conjugate

Stampa

Cat# 75-057-FL550

Size : 200uL

Contatta il distributore locale :

Telefono : +1 850 650 7790

Marca : Antibodies Incorporated

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Contatta il distributore locale :

Telefono : +1 850 650 7790

SKU: 75-057-FL550

Product Details

Target

Chapsyn-110/PSD-93

Target Description

PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N18/30

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Dlg2 Dlgh2

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 1-852 of rat Chapsyn-110 (accession number Q63622) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rabbit, Rat

Antibody Registry ID

AB_2939249

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

No cross-reactivity against other MAGUK family members PSD-95, SAP97, SAP102 expressed in transfected cells

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

UniProt ID

Q63622

Anti-Chapsyn-110/PSD-93 Antibody FL550 Conjugate

Cat# 75-057-FL550

Contatta il distributore locale :

Marca : Antibodies Incorporated

Contatta il distributore locale :

SKU: 75-057-FL550

Product Details

Bulk Order Anti-Chapsyn-110/PSD-93 Antibody FL550 Conjugate