Anti-PDE4D antibody {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.2 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PDE4D
Gene ID:	5144
Uniprot ID:	PDE4D_HUMAN
Immunogen:	Synthetic peptide corresponding to unique amino acid sequence on PDE4D8 variant gene.

Tissue Specificity	Expressed in colonic epithelial cells (at protein level). Widespread.most abundant in skeletal muscle. Isoform 6: Detected in brain. Isoform 8: Detected in brain, placenta, lung and kidney. Isoform 7: Detected in heart and skeletal muscle.
Post Translational Modifications	Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation. Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59. Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation.
Function	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Protein Name	Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4d Dpde3 Pde43
Database Links	Reactome: R-HSA-180024 Reactome: R-HSA-418555
Cellular Localisation	Apical Cell Membrane Cytoplasm Membrane Cytoskeleton Microtubule Organizing Center Centrosome Found In The Soluble Fraction Associated With Membranes And Associated With The Cytoskeleton And The Centrosome Colocalized With Shank2 To The Apical Membrane Of Colonic Crypt Cells
Alternative Antibody Names	Anti-Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4d antibody Anti-Dpde3 antibody Anti-Pde43 antibody Anti-PDE4D antibody Anti-DPDE3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance