Anti-TLR2 (RABBIT) Antibody
Cat# 600-401-956
Size : 100ug
Marca : Rockland Immunochemicals
Contatta il distributore locale :
Telefono : +1 850 650 7790
Specifications for TLR2 Antibody
Product Details
Anti-TLR2 (RABBIT) Antibody - 600-401-956
CD282 antibody, Toll like receptor 2 antibody, Toll like receptor 2 precursor antibody, Toll/interleukin 1 receptor like 4 antibody, Toll/interleukin receptor like protein 4 antibody, TIRAP, MAL, TIR domain containing adaptor protein
Rabbit
Polyclonal
IgG
Target Details
TLR2 - View All TLR2 Products
Human, Mouse
Conjugated Peptide
TLR2 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the n-terminus of human TLR2.
Anti-TLR2 Antibody is affinity chromatography purified via peptide column. A BLAST analysis was used to suggest cross-reactivity with TLR2 with Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with TLR2 from other sources has not been determined.
O60603 - UniProtKB
NP_001305716.1 - NCBI Protein
7097 - Gene ID
Application Details
ELISA, IF, IHC, WB
Other - View References
TLR2 antibody has been tested for use in ELISA, immunohistochemistry, immunofluorescence, and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 100 kDa in size corresponding to TLR2 protein by western blotting in the appropriate cell lysate or extract.
Formulation
1.0 mg/mL by UV absorbance at 280 nm
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.02% (w/v) Sodium Azide
None
Shipping & Handling
Dry Ice
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of receipt.
Background
TLR2 (Toll Like Receptor 2). Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer can recognize a variety of bacterial and mycoplasma lipoproteins, respectively. Anti-TLR2 antibody is ideal for investigators involved in cytokines and growth factors research.
References (4)
Hiltunen N et al. (2024). Toll-like receptors 1-9 in small bowel neuroendocrine tumors-Clinical significance and prognosis. PLoS One.
Applications
IHC, ICC, Histology PubMed
Domon, H et al. (2018). Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia. Frontiers in Immunology
Applications
WB, IB, PCA PubMed
Ryu, S et al. (2015). Suppression of Propionibacterium acnes Infection and the Associated Inflammatory Response by the Antimicrobial Peptide P5 in Mice. PloS One
Applications
IF, Confocal Microscopy PubMed
Sweeney, TE et al. (2011). A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. PloS One
Applications
RNA seq, qPCR, Reverse Transcription, RT-PCR Analysis PubMed
Related Protocols
Adherent Cell Lysis Protocol
ELISA Protocol
Fluorescent Western Blotting Protocol
Heat-induced Antigen Retrieval Protocol
Histone Immunoblotting Protocol
Immunocytochemistry (ICC) Protocol
Immunofluorescence (IF) Protocol
Immunohistochemistry (IHC) Protocol
In-Cell Western (ICW) Protocol
IP-WB with TrueBlot® Protocol
Multi-Lysate Western Blotting Protocol
Nuclear & Cytoplasmic Extract Protocol
Protease-induced Antigen Retrieval Protocol
Sandwich ELISA Protocol for Collagen
Staining Paraffin Sections by PAP Procedure
Suspension Cultured Cell Lysis Protocol
Western Blotting (WB) Protocol
Certificate of Analysis Lookup
Disclaimer
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
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