BDNF Protein

Cat# OPPA00472

Size : 2ug

Marca : Aviva Systems Biology

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Datasheets/ManualsPrintable datasheet for OPPA00472
Product Info
Predicted Species ReactivityHuman
Product FormatLyophilized without additives.
Physical appearance: Sterile filtered white powder..
::Protein Content: BDNF quantitation was carried out by two independent methods.
1. UV spectroscopy at 280 nm using the absorbency value of 1.6 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
2. Analysis by RP-HPLC, using a standard solution of Brain-derived Neurotrophic Factor as a Reference Standard.
Reconstitution and StorageIt is recommended to reconstitute the lyophilized Brain-derived Neurotrophic Factor in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Lyophilized BDNF although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Brain-derived Neurotrophic Factor should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
PurificationBDNF Human Recombinant is purified by proprietary chromatographic techniques.
PurityGreater than 97.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Biological ActivityThe ED50, as determined by the dose-dependent induction of C6 cells proliferation, is 1.3-2 ug/ml.
SourceE.coli
Gene SymbolBDNF
Gene Full NameBrain-derived neurotrophic factor
Alias SymbolsANON2, BULN2
NCBI Gene Id627
Protein NameBrain-derived neurotrophic factor
Description of TargetBDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the cns. the versatility of bdnf is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (ltp), long-term depression (ltd), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Uniprot IDP23560
Protein Accession #NP_001137277.1
Protein Size (# AA)Recombinant
Molecular Weight27 kDa

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