Nitrocefin [41906-86-9]

Cat# B6052-10mg

Size : 10mg

Marca : APExBIO Technology

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Nitrocefin

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Background

Nitrocefin is a chromogenic cephalosporin substrate which is used for detection of β-lactamases. β-lactamases are enzymes produced by various microbes that mediate resistance to β-lactam antibiotics such as penicillins and  cephamycins. Comparing to other methods for β-lactamases detection, nitrocefin is more sensitive while using few materials and inexpensive equipment. The color change by nitrocefin can be followed quantitatively by measuring changes in absorption between 380 to 500 nm region[1].

Reference:
[1] O'Callaghan, Cynthia H et al.  Novel Method for Detection of B-Lactamases by Using a Chromogenic Cephalosporin Substrate. Antimicrobial Agents and Chemotherapy. 1972 Apr; 1(4):283-288.

Product Citation

  • 1. Liu X, Ma L, et al. "Synergistic antibacterial mechanism of Bi(2)Te(3) nanoparticles combined with the ineffective β-lactam antibiotic cefotaxime against methicillin-resistant Staphylococcus aureus." J Inorg Biochem. 2019 Jul;196:110687." PMID:31004991

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt516.50
Cas No.41906-86-9
FormulaC21H16N4O8S2
Solubilityinsoluble in EtOH; insoluble in H2O; ≥20.24 mg/mL in DMSO
Chemical Name(6R,7R)-3-((E)-2,4-dinitrostyryl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SDFDownload SDF
Canonical SMILES04[C@]1([C@@H]2NC(CC3=CC=CS3)=O)SCC(/C=C/C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)=C(C(O)=O)N1C2=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

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