Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare
 
> NSC 617145

NSC 617145

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Cat# 461011-5mg

Size : 5mg

Marca : US Biological

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461011 NSC 617145

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
RT
Storage Temp
-20°C

NSC 617145 is a helicase inhibitor used in the treatment of Werner syndrome helicase and acts synergistically with Mitomycin C, an antitumor antibiotic. It is used as antineoplastic.||Synonyms:|1,1'-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione||CAS No:|203115-63-3||Molecular Formula:|C₁₃H₁₀Cl₄N₂O₄||Molecular Weight:|400.04||Purity:|≥98% (HPLC)||Appearance:|White to off-white powder||Solubility (20mM):|DMSO||Microanalysis:|Calculated: %C: 38.60, %H: 2.62, %N: 6.92||Method for Determining Identity:|Proton NMR Spectroscopic and Mass Spectrometric analysis||Storage and Stability:|Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971). 2. Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 16, 361 (1986). 3. Aggarwal et al (2013) Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73 5497 PMID: 23867477. 4. Aggarwal et al (2013) Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 12 3329 PMID: 24036544

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