Pembrolizumab [1374853-91-4]
Cat# HY-P9902-1mg
Size : 1mg
Marca : MedChemExpress
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.
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Pembrolizumab Chemical Structure
CAS No. : 1374853-91-4
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Based on 10 publication(s) in Google Scholar
Description |
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy. |
IC50 & Target |
IC50: 0.6 nM (PD-1) |
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In Vitro |
Pembrolizumab (MK-3475) increases the secretion of cytokines IFN-γ, TNF-α and the apoptotic cell death of A549 cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity Assay[2]
Apoptosis Analysis[2]
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In Vivo |
Pembrolizumab inhibits tumor size in A549 xenograft mice pretreated by pressure[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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CAS No. |
1374853-91-4 |
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Appearance |
Liquid |
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Color |
Colorless to light yellow |
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SMILES |
[Pembrolizumab] |
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Livraison | Shipping with dry ice. |
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Stockage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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Pureté et documentation |
Purity: 99.17% |
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Références |
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Pembrolizumab Related Classifications
- Immunology/Inflammation
- PD-1/PD-L1
Calculateur de molarité
Calculateur de dilution
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Pembrolizumab1374853-91-4MK-3475 LambrolizumabMK3475MK 3475PD-1/PD-L1PD-1/Programmed death-ligand 1PD-1 inhibitorIgG4 antibody cancerimmunologyInhibitorinhibitorinhibit