K1007-1ml | Protease Inhibitor Cocktail(EDTA-Free,100X in DMSO) Clinisciences

Product Citation

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Thaw at room temperature, add at 1:100 (v/v) dilution to solution samples (such as cell lysates or tissue extracts) before assaying.

Applications: WB, Co-IP, pull-down, IF, IHC, kinase assay and etc.

Components and Storage

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A2573	AEBSF.HCl	Serine protease inhibitor	Proteases\|Serine Protease	30827-99-7	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
A2574	Aprotinin	Inhibitor of bovine pancreatic trypsin	Proteases\|Serine Protease	9087-70-1
A2575	Bestatin	Aminopeptidase inhibitor	Proteases\|Aminopeptidase	58970-76-6	CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O
A2576	E-64	Cysteine protease inhibitor,irreversible	Proteases\|Cathepsin	66701-25-5	CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
A2570	Leupeptin	Inhibitor of serine and cysteine proteases	Proteases\|Serine Protease	103476-89-7	O=C(C(C(00)(00)C(C(00)(00)00)(00)C(00)(00)00)(00)N(00)C(C(00)(00)00)=O)N(00)C(C(N(00)C(C(00)=O)(00)C(00)(00)C(00)(00)C(00)(00)/N=C(N(00)00)/N(00)00)=O)(00)C(00)(00)C(C(00)(00)00)(00)C(00)(00)00
A2571	Pepstatin A	Aspartic protease inhibitor	Proteases\|Other Proteases	26305-03-3	CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O
Stored at -20°C, and stable for at least 12 months.

Description

Endogenous proteins are produced and degraded in a balanced state, so their cellular levels are stable under stable environmental conditions. Crude cell extracts contain a number of endogenous enzymes, such as phosphatases and proteases, which are capable of degrading proteins in the extracts. Protein production is greatly halted and degradation is increased when proteins are extracted from cells and tissues in vitro. The best way to increase the yield of intact proteins is to add inhibitors of those enzymes known to be present.

Protease inhibitor cocktail is used in cell lysates or tissue extracts to increase protein stability. The cocktail functions to inhibit proteases that would degrade either non-phosphorylated or phosphorylated protein substrates.

This protease inhibitor cocktail contains individual components, including AEBSF, Aprotinin, Bestatin, E-64, Leupeptin and Pepstatin A with a broad specificity for cysteine, serine, acid proteases, and aminopeptidases. This protease inhibitor cocktail has been optimized and tested for mammalian cells and tissue extracts. This protease inhibitor cocktail is supplied as a ready-to-use solution in DMSO.

Storage

Stored at -20°C, and stable for at least 12 months.

Protease Inhibitor Cocktail(EDTA-Free,100X in DMSO)

Cat# K1007-1ml

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Components and Storage

Description

Storage

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