Molecular purification methods such as immunoprecipitation (IP), co-IP and chromatin IP are important tools in studying lowly expressed proteins, protein-protein interactions or protein-nucleic acid interactions. Santa Cruz Biotechnology offers a comprehensive array of research support products for purification techniques. Protein A/G PLUS is an essential specialty reagent used for isolating immunoglobulins from nearly any mammalian species. Protein A/G PLUS is a genetically-engineered protein that combines binding profiles of Protein A and Protein G, thereby producing an exceptionally high-capacity reagent. Protein A/G PLUS works through non-covalent high affinity binding of either protein A or protein G to the Fc regions of mammalian antibody isotypes, specifically IgG, IgA, IgE and IgM. Protein A/G PLUS is a powerful reagent for purification and detection of mouse monoclonal antibodies from IgG subclasses without interference from other serum proteins. Protein A/G PLUS is linked to a high-quality Agarose resin, CL-6B, which makes it a superior and premium product that produces high purity and purification yield of IgGs from mammalian samples.

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