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> Ranolazine (dihydrochloride) [95635-56-6]

Ranolazine (dihydrochloride) [95635-56-6]

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Cat# HY-17401-100mg

Size : 100mg

Marca : MedChemExpress

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Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor.

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Ranolazine dihydrochloride Chemical Structure

Ranolazine dihydrochloride Chemical Structure

CAS No. : 95635-56-6

This product is a controlled substance and not for sale in your territory.

Based on 5 publication(s) in Google Scholar

Other Forms of Ranolazine dihydrochloride:

  • Ranolazine-d8 dihydrochloride In-stock
  • Ranolazine In-stock

    Ranolazine dihydrochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Oct 29;8(19):5452-5468.  [Abstract]

    Western Blot analysis of vector or PITPNC1 overexpressing BGC823 and AGS which are seeded and treated with Ranolazine.
    Description

    Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].

    IC50 & Target

    IC50: 6 μM (INa), 12 μM (IKr)[1]
    In Vivo

    Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats (240-350 g)[3]
    Dosage: Bolus injection 10 mg/kg and infusion (9.6 mg/kg/h)
    Administration: Bolus injection; for 145 minutes
    Result: Significantly reduced infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.
    Essai clinique
    Masse moléculaire

    500.46

    Formule

    C24H35Cl2N3O4
    CAS No.

    95635-56-6
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(NC1=C(C)C=CC=C1C)CN2CCN(CC(O)COC3=CC=CC=C3OC)CC2.18Cl.18Cl
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvant et solubilité
    In Vitro: 

    DMSO : ≥ 50 mg/mL (99.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 50 mg/mL (99.91 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9982 mL 9.9908 mL 19.9816 mL
    5 mM 0.3996 mL 1.9982 mL 3.9963 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (199.82 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureté et documentation

    Purity: 99.79%

    COA (246 KB) HNMR (257 KB) LCMS (253 KB)

    Instruction de manipulation (2659 KB)
    Références

    • [1]. Keating GM. Ranolazine: A Review of Its Use as Add-On Therapy in Patients with Chronic Stable Angina Pectoris. Drugs. 2013 Jan;73(1):55-73.  [Content Brief]

      [2]. Wang WQ, Robertson C, Dhalla AK, Belardinelli L. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81. doi: 10.1124/jpet.108.137729. Epub 2008 Mar 5.  [Content Brief]

      [3]. Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.  [Content Brief]

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 1.9982 mL 9.9908 mL 19.9816 mL 49.9540 mL
    5 mM 0.3996 mL 1.9982 mL 3.9963 mL 9.9908 mL
    10 mM 0.1998 mL 0.9991 mL 1.9982 mL 4.9954 mL
    15 mM 0.1332 mL 0.6661 mL 1.3321 mL 3.3303 mL
    20 mM 0.0999 mL 0.4995 mL 0.9991 mL 2.4977 mL
    25 mM 0.0799 mL 0.3996 mL 0.7993 mL 1.9982 mL
    30 mM 0.0666 mL 0.3330 mL 0.6661 mL 1.6651 mL
    40 mM 0.0500 mL 0.2498 mL 0.4995 mL 1.2489 mL
    50 mM 0.0400 mL 0.1998 mL 0.3996 mL 0.9991 mL
    60 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8326 mL
    80 mM 0.0250 mL 0.1249 mL 0.2498 mL 0.6244 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Ranolazine dihydrochloride Related Classifications

    Help & FAQs

    Keywords:

    Ranolazine95635-56-6CVT 303 RS 43285CVT303CVT-303RS43285RS 43285RS-43285Calcium ChannelSodium ChannelAutophagyCa2+ channelsCa channelsNa channelsNa+ channelsInhibitorinhibitorinhibit

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