SAG (S Antigen, S-AG, Retina And Pineal Gland, Arrestin, 48 kDa protein, Retinal S-antigen, Rod photoreceptor arrestin)

Cat# 364970-200ul

Size : 200ul

Marca : US Biological

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364970 SAG (S Antigen, S-AG, Retina And Pineal Gland, Arrestin, 48 kDa protein, Retinal S-antigen, Rod photoreceptor arrestin)

Clone Type
Polyclonal
Host
rabbit
Source
human
Swiss Prot
P10523
Isotype
IgG
Grade
Affinity Purified
Applications
E IC IHC WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

S-antigen; retina and pineal gland is a Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.||Applications: |Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested.||Recommended Dilution:|ELISA: 1:100-1:5000|Western Blot: 1:50-400|Immunocytochemistry: 1:50-500|Immunohistochemistry (frozen): 1:50-500|Immunohistochemistry (paraffin): 1:10-100|Optimal dilutions to be determined by the researcher.||AA Sequence:|MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- AP QDSGKSCGVD FEVKAFATDS TDAEEDKIPK KSSVRLLIRK VQHAPLEMGP QPRAEAAWQF FMSDKPLHLA VSLNKEIYFH GEPIPVTVTV TNNTEKTVKK IKAFVEQVAN VVLYSSDYYV KPVAMEEAQE KVPPNSTLTK TLTLLPLLAN NRERRGIALD GKIKHEDTNL ASSTIIKEGI DRTVLGILVS YQIKVKLTVS GFLGELTSSE VATEVPFRLM HPQPEDPAKE SYQDANLVFE EFARHNLK||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Applications
Product Type: Pab|Isotype: IgG|Host: rabbit|Source: human|Concentration: ~0.5mg/ml|Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.|Purity: Purified by immunoaffinity chromatography.|Immunogen: Recombinant protein corresponding to Ala139-Lys388 of human SAG, expressed in E. coli.|Specificity: Recognizes human SAG. ||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Recombinant protein corresponding to Ala139-Lys388 of human SAG, expressed in E. coli.
Form
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SAG.