Tenuazonic acid [610-88-8]
Cat# HY-N6715-1mg
Size : 1mg
Marca : MedChemExpress
Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor.
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Tenuazonic acid Chemical Structure
CAS No. : 610-88-8
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Tenuazonic acid:
- Tenuazonic acid-13C10 Obtenir un devis
Description |
Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate[1]. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor[2]. |
IC50 & Target |
PSII[2] |
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Masse moléculaire |
197.23 |
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Formule |
C10H15NO3 |
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CAS No. |
610-88-8 |
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Appearance |
Solid |
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Color |
Light yellow to brown |
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SMILES |
O=C1N[C@@H]([C@@H](C)CC)C(O)=C1C(C)=O |
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Structure Classification |
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Initial Source |
Alternaria alternata |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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Solvant et solubilité |
In Vitro:
DMSO : 50 mg/mL (253.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 5.0702 mL | 25.3511 mL | 50.7022 mL | 126.7556 mL |
5 mM | 1.0140 mL | 5.0702 mL | 10.1404 mL | 25.3511 mL | |
10 mM | 0.5070 mL | 2.5351 mL | 5.0702 mL | 12.6756 mL | |
15 mM | 0.3380 mL | 1.6901 mL | 3.3801 mL | 8.4504 mL | |
20 mM | 0.2535 mL | 1.2676 mL | 2.5351 mL | 6.3378 mL | |
25 mM | 0.2028 mL | 1.0140 mL | 2.0281 mL | 5.0702 mL | |
30 mM | 0.1690 mL | 0.8450 mL | 1.6901 mL | 4.2252 mL | |
40 mM | 0.1268 mL | 0.6338 mL | 1.2676 mL | 3.1689 mL | |
50 mM | 0.1014 mL | 0.5070 mL | 1.0140 mL | 2.5351 mL | |
60 mM | 0.0845 mL | 0.4225 mL | 0.8450 mL | 2.1126 mL | |
80 mM | 0.0634 mL | 0.3169 mL | 0.6338 mL | 1.5844 mL | |
100 mM | 0.0507 mL | 0.2535 mL | 0.5070 mL | 1.2676 mL |
Tenuazonic acid Related Classifications
- Anti-infection
- Influenza Virus Bacterial