Focus on Toll Like Receptor
Innate immunity
The innate immune system plays an essential role in the host's first line of defense againt microbial invasion and involves
the recognition of pathogen-associated molecular patterns (PAMPs) or endogenous danger signals through the sensing
of danger-associated molecular patterns by pattern recognition receptors.
The Toll Like Receptors (TLRs) are type I membrane glycoproteins capable of detecting PAMPs in extracellular milieu
The Toll Like Receptors (TLRs) are type I membrane glycoproteins capable of detecting PAMPs in extracellular milieu
and endosomal compartments.
The activation of TLR signaling pathways results in the production and release of various cytokines and chemokines.
| TLR Receptors agonists | Negative Regulator of innate immunity | ||
| TLR1/2 | TL R7/8 |  TLR7 agonists
|
NLRC3 is a cytoplasmic protein that negatively regulates pro-IL-1B expression and inhibits TLR-dependent activation of the transcription factor NF-kB. It also reduces STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP and DNA viruses. |
| TLR5 | TLR9 | ||
| TLR6/2 | TLR11 | ||
| TLR7 | TL R11/12 | ||
| Available products for each TLR | ||
| Antibodies (human, mouse, rat) |
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ELISA (human, mouse, rat) |
| RNAi | Blocking peptides | |
| cDNA | Protein, Peptides | |
| CRISPR/Cas9 | Primers | |