B3513-500mg | Ademetionine [29908-03-0] Clinisciences

Background

Ademetionine (S-adenosylmethionine; SAMe) is a naturally occurring metabolite present in all cells and biological fluids, and acts as a methyl donor in a variety of methylation reactions involving proteins, phospholipids, catecholamines and DNA. Ademetionine exhibits antidepressant activity associated with increases in brain monoamine neurotransmitters and improvement in muscarinic and β-adrenergic receptor functions. In addition, preliminary studies imply that ademetionine exhibits therapeutic potential in the treatment of other central nervous system disorders including dementia, acquired immune deficiency syndrome-associated myelopathy, as well as brain ischemia.

Reference:

1. Bottiglieri T. Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders. Expert Opinion on Investigational Drugs, 1997, 6(4): 417-426.

Chemical Properties

Storage	Store at -20°C
M.Wt	398.44
Cas No.	29908-03-0
Formula	C₁₅H₂₂N₆O₅S
Solubility	insoluble in EtOH; ≥108 mg/mL in H2O; ≥110.8 mg/mL in DMSO
Chemical Name	(2S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate
SDF	Download SDF
Canonical SMILES	C[S+](C[C@](O1)(14)[C@](O)(14)[C@](O)(14)[C@]1(14)N2C=NC(C2=NC=N3)=C3N)CC[C@@](N)(14)C([O-])=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment:[1]
Animal models	Mice and rats
Dosage form	12.5, 25, 50, 100 and 200 mg/kg Subcutaneous injection
Applications	Ademetionine dose-dependently decreased immobility time in the forced swimming test in mice and rats, and the effect could be antagonized by haloperiodol.
Note	The technical data provided above is for reference only.
	References: 1. Bottiglieri T. Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders. Expert Opinion on Investigational Drugs, 1997, 6(4): 417-426.

Quality Control

Purity = 98.00%

COA (Certificate Of Analysis)
MSDS (Material Safety Data Sheet)

Chemical structure

Ademetionine [29908-03-0]

Referentie B3513-500mg

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