APH1A, NT (APH1A, PSF, Gamma-secretase subunit APH-1A, Aph-1alpha, Presenilin-stabilization factor) (Azide free) (HRP)

Referentie 031970-HRP-200ul

Formaat : 200ul

Merk : US Biological

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031970-HRP APH1A, NT (APH1A, PSF, Gamma-secretase subunit APH-1A, Aph-1alpha, Presenilin-stabilization factor) (Azide free) (HRP) discontinued

Clone Type
Polyclonal
Host
rabbit
Source
mouse
Swiss Prot
Q96BI3
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Mo
Accession #
NP_057106.2
Gene #
APH1A
Shipping Temp
Blue Ice
Storage Temp
-20°C

APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).||Applications:|Suitable for use in Western Blot, ELISA||Recommended Dilution:|ELISA: 1:1,000|Western Blot: 1:100-500||Storage and Stability:|Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. ||Note: Applications are based on unconjugated antibody.

Applications
Product Type: Pab|Isotype: IgG|Host: rabbit|Source: mouse|Concentration: As reported|Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).|Purity: Purified by Protein A affinity chromatography.|Immunogen: APH1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-70 amino acids from the N-terminal region of human APH1A.|Specificity: Mouse||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
APH1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-70 amino acids from the N-terminal region of human APH1A.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Purity
Purified by Protein A affinity chromatography.
Specificity
Mouse
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Mitsuishi, Y., et al. J. Biol. Chem. 285(20):14920-14931(2010)|Chen, A.C., et al. J. Biol. Chem. 285(15):11378-11391(2010)|Pardossi-Piquard, R., et al. J. Biol. Chem. 284(24):16298-16307(2009)|Wang, Y., et al. Neurosci. Lett. 455(2):101-104(2009)