Briciclib [865783-99-9]
Referentie HY-16366-1mg
Formaat : 1mg
Merk : MedChemExpress
Briciclib (ON 014185) is a derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
Briciclib Chemical Structure
CAS No. : 865783-99-9
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Briciclib:
- ON-013100 In-stock
Description |
Briciclib (ON 014185) is a derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target |
|
||||||||||||
In Vitro |
Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
Essai clinique |
|
||||||||||||
Masse moléculaire |
474.42 |
||||||||||||
Formule |
C19H23O10PS |
||||||||||||
CAS No. |
865783-99-9 |
||||||||||||
Appearance |
Solid |
||||||||||||
Color |
White to off-white |
||||||||||||
SMILES |
O=S(CC1=CC(OP(O)(O)=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O |
||||||||||||
Livraison | Room temperature in continental US; may vary elsewhere. |
||||||||||||
Stockage |
|
||||||||||||
Solvant et solubilité |
In Vitro:
DMSO : ≥ 31 mg/mL (65.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
|
||||||||||||
Pureté et documentation |
Purity: 99.63 |
||||||||||||
Références |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
DMSO | 1 mM | 2.1078 mL | 10.5392 mL | 21.0784 mL | 52.6959 mL |
5 mM | 0.4216 mL | 2.1078 mL | 4.2157 mL | 10.5392 mL | |
10 mM | 0.2108 mL | 1.0539 mL | 2.1078 mL | 5.2696 mL | |
15 mM | 0.1405 mL | 0.7026 mL | 1.4052 mL | 3.5131 mL | |
20 mM | 0.1054 mL | 0.5270 mL | 1.0539 mL | 2.6348 mL | |
25 mM | 0.0843 mL | 0.4216 mL | 0.8431 mL | 2.1078 mL | |
30 mM | 0.0703 mL | 0.3513 mL | 0.7026 mL | 1.7565 mL | |
40 mM | 0.0527 mL | 0.2635 mL | 0.5270 mL | 1.3174 mL | |
50 mM | 0.0422 mL | 0.2108 mL | 0.4216 mL | 1.0539 mL | |
60 mM | 0.0351 mL | 0.1757 mL | 0.3513 mL | 0.8783 mL |