Dapagliflozin impurity [960404-86-8]
Referentie HY-128723-1ml
Formaat : 10mM/1mL
Merk : MedChemExpress
Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor.
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Dapagliflozin impurity Chemical Structure
CAS No. : 960404-86-8
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Based on 1 publication(s) in Google Scholar
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Description |
Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor[1]. |
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Masse moléculaire |
424.87 |
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Formule |
C21H25ClO7 |
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CAS No. |
960404-86-8 |
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Appearance |
Solid |
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Color |
Off-white to light yellow |
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SMILES |
O[C@]1(C2=CC=C(Cl)C(CC3=CC=C(OCC)C=C3)=C2)[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 25 mg/mL (58.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.3537 mL | 11.7683 mL | 23.5366 mL | 58.8415 mL |
5 mM | 0.4707 mL | 2.3537 mL | 4.7073 mL | 11.7683 mL | |
10 mM | 0.2354 mL | 1.1768 mL | 2.3537 mL | 5.8842 mL | |
15 mM | 0.1569 mL | 0.7846 mL | 1.5691 mL | 3.9228 mL | |
20 mM | 0.1177 mL | 0.5884 mL | 1.1768 mL | 2.9421 mL | |
25 mM | 0.0941 mL | 0.4707 mL | 0.9415 mL | 2.3537 mL | |
30 mM | 0.0785 mL | 0.3923 mL | 0.7846 mL | 1.9614 mL | |
40 mM | 0.0588 mL | 0.2942 mL | 0.5884 mL | 1.4710 mL | |
50 mM | 0.0471 mL | 0.2354 mL | 0.4707 mL | 1.1768 mL |
Dapagliflozin impurity Related Classifications
- Membrane Transporter/Ion Channel
- SGLT