FAK(Ser910) Polyclonal Antibody, PerCP-Cy7 Conjugated
Referentie bs-13133R-PerCP-Cy7
Formaat : 100ul
Merk : Bioss
FAK(Ser910) Polyclonal Antibody, PerCP-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-13133R-PerCP-Cy7 |
Product Name | FAK(Ser910) Polyclonal Antibody, PerCP-Cy7 Conjugated |
Applications | WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
Reactivity | Mouse, Rat, Xenopus laevis |
Predicted Reactivity | Human, Chicken |
Specifications | |
Conjugation | PerCP-Cy7 |
Host | Rabbit |
Source | KLH conjugated synthetic phosphopeptide derived from human PTK2 around the phosphorylation site of Tyr910 |
Modification Site | Ser910 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 5747 |
Subcellular location | Cytoplasm, Nucleus, Cell membrane |
Synonyms | FAK phospho S910; p-FAK phospho S910; FADK 1; FADK; FAK 1; FAK related non kinase polypeptide; FAK1; Focal adhesion kinase 1; FRNK; pp125FAK; Protein tyrosine kinase 2; Protein Tyrosine Kinase Cytoplasmic; PTK 2; FAK1_HUMAN; Focal adhesion kinase-related nonkinase; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK. |
Background | Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity. |
Application Dilution | |
WB | 1:300-5000 |
IF(IHC-P) | 1:50-200 |
IF(IHC-F) | 1:50-200 |
IF(ICC) | 1:50-200 |