Our FGFR3 probe is designed to detect the FGFR3 amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
Gene Background: FGFR3 is a member of the FGFR gene family, tyrosine kinases with extracellular immunoglobulin (Ig)-like domains and intracellular tyrosine kinase domains. The FGFR signaling pathway interacts with several other important intracellular pathways, including PI3K/Akt, Wnt, hedgehog, and bone morphogenic protein (BMP). FGFR copy number variations have been detected in 19% of bladder urothelial carcinomas, and, at lower frequencies, squamous cell lung carcinoma, melanoma, glioblastoma, bladder carcinoma, and gastric adenocarcinoma.
Source: Helsten T, et al. (2015) Cancer & Metastasis Rev 34.3:479-496.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: FGFR3
Gene Name: Fibroblast Growth Factor Receptor 3
Chromosome: CHR4: 1795038-1810599
Locus: 4p16.3