General Info
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.116ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This GRIA3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
Information
| Gene Symbol: | GRIA3 |
| Gene ID: | 2892 |
| Uniprot ID: | GRIA3_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
Description
| Tissue Specificity | |
| Post Translational Modifications | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 3Glur-3Ampa-Selective Glutamate Receptor 3Glur-CGlur-K3Glutamate Receptor Ionotropic - Ampa 3Glua3 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneInteraction With Cnih2 And Cnih3 Promotes Cell Surface Expression |
| Alternative ELISA Names | Glutamate Receptor 3 ELISA kitGlur-3 ELISA kitAmpa-Selective Glutamate Receptor 3 ELISA kitGlur-C ELISA kitGlur-K3 ELISA kitGlutamate Receptor Ionotropic - Ampa 3 ELISA kitGlua3 ELISA kitGRIA3 ELISA kitGLUR3 ELISA kitGLURC ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance