Hydroxychloroquine

Biological Activity

Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection.

Product Citations

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  J Sci Food Agric. 2023 May 1.

  Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cells balance via TLR9-MyD88-STAT3 signaling pathway
  Hydroxychloroquine purchased from AbMole

Chemical Information

Molecular Weight	335.87
Formula	C18H26ClN3O
CAS Number	118-42-3
Solubility (25°C)	DMSO 90 mg/mL 1M HCl: 80 mg/mL (adjust pH to 2 with HCl)
Storage	RT, protect from light, dry, sealed

References

[1] Akrithi Udupa, et al. Curr Allergy Asthma Rep. Hydroxychloroquine and COVID-19: a Rheumatologist's Take on the Lessons Learned

[2] Wesley H Self, et al. JAMA. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial

[3] Pankaj Bansal, et al. Ann Med. Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019

[4] Praveen Balabaskaran Nina, et al. Indian J Public Health. Hydroxychloroquine as prophylaxis or treatment for COVID-19: What does the evidence say?

[5] C Ponticelli, et al. Expert Opin Drug Saf. Hydroxychloroquine in systemic lupus erythematosus (SLE)