Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isavuconazole [241479-67-4]
Referentie T2305-25mg
Formaat : 25mg
Merk : TargetMol
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Isavuconazole
Catalog No. T2305 CAS 241479-67-4
Synonyms: BAL-4815, RO-0094815
Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata.
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Isavuconazole, CAS 241479-67-4
| Pack Size | /USD | |
|---|---|---|
| 1 mg | In stock | |
| 2 mg | In stock | |
| 5 mg | In stock | |
| 10 mg | In stock | |
| 25 mg | In stock | |
| 50 mg | In stock | |
| 100 mg | In stock | |
| 200 mg | In stock | |
| 500 mg | In stock | |
| 1 mL * 10 mM (in DMSO) | In stock |
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Purity: 100%
Purity: 99.97%
Purity: 99.97%
Purity: 98%
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| Description | Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata. |
| Kinase Assay | SP2509 activity assays: Test compounds are diluted to 20 × the desired test concentration in 100% DMSO and 2.5?μL of the diluted drug sampleis added to a black 384-well plate. The LSD1 enzyme stock is diluted 17-fold with assay buffer and 40?μL of the diluted LSD1 enzyme is added to the appropriate wells. Substrate, consisting of horseradish peroxidase, dimethyl K4 peptide corresponding to the first 21 amino acids of the N-terminal tail of histone H3, and 10-acetyl-3,7-dihydroxyphenoxazine is then added to wells. Resorufin is analyzed on an Envision plate reader with an excitation wavelength of 530?nm and an emission wavelength of 595?nm. The activity of SP2509 on the other oxidases is determined by using commercially available kits. The glucose oxidase activity (which also noncovalently binds FAD in an elongate conformation), is determined using the glucose oxidase kit. The MAO assays are performed using the MAO-glo kit with MAO-A and MAO-B. |
| Synonyms | BAL-4815, RO-0094815 |
| Molecular Weight | 437.47 |
| Formula | C22H17F2N5OS |
| CAS No. | 241479-67-4 |
Storage
Solubility Information
DMSO: 70 mg/mL (160.01 mM)
References and Literature
1. Seifert H, et al. Antimicrob Agents ChemOthers. 2007 May;51(5):1818-21. 2. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China[J]. Mycoses. 2019 May;62(5):450-457. 3. Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing[J]. Mycoses. 2020, 63(12): 1283-1298. 4. Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing[J]. Emerging Microbes & Infections. 2020: 1-53. 5. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing[J]. Emerging microbes & infections. 2019;8(1):531-541.
Citations
1. Ma L, Lian Y, Tang J, et al. Identification of the Anti-Fungal Drug Fenticonazole Nitrate as a Novel PPARγ-Modulating Ligand With Good Therapeutic Index: Structure-Based Screening and Biological Validation. Pharmacological Research. 2021: 105860. 2. Quan C, Chen Y, Wang X, et al. Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Cancer Letters. 2020 3. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing. Emerging Microbes & Infections. 2019, 8(1): 531-541 4. Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing. Emerging Microbes & Infections. 2021 Dec;10(1):81-96. 5. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China. Mycoses. 2019, 62(5): 450-457
Related compound libraries
This product is contained In the following compound libraries：
Anti-Cancer Clinical Compound Library EMA Approved Drug Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Human Metabolite Library Clinical Compound Library
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Keywords
Isavuconazole 241479-67-4 Metabolism Microbiology/Virology P450 Antifungal Antibiotic prodrug dimorphic Inhibitor ergosterol CYPs RO 0094815 triazole BAL4815 biosynthesis Fungal fungi RO0094815 yeasts BAL-4815 inhibit BAL 4815 Cytochrome P450 RO-0094815 molds inhibitor