In 1976, Guilbert and Iscove demonstrated that precursor cells of erythrocytes and macrophages|could be cultured in a reduced-serum medium supplemented with albumin, transferrin, lecithin, and selenium. Iscove's medium is a modification of Dulbecco's Modified Eagle's Medium (DME)|containing selenium, additional amino acids and vitamins, sodium pyruvate, HEPES buffer, and|potassium nitrate instead of ferric nitrate.||Appearance: |Off-white to light yellow, homogeneous, free flowing powder.||Solubility: |Colorless to light yellow, clear, complete||pH: |As Reported||Endotoxin: |≤1EU/ml|||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.