A3516-5mg | JC-1 [3520-43-2] Clinisciences

Background

JC-1 is a dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent (λex 520 nm) monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent (λem 596 nm ) "J-aggregates," which exhibit broad excitation and very narrow emission spectra. The ratio of red to green fluorescence of JC-1 is dependent only on membrane potential, and not influenced by mitochondrial size, shape, or density. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green, while in healthy cells, the dye aggregates in the mitochondria and fluoresces red.

Product Citation

1. Xiao‑Xin Yang, Xiang Xu, et al. "A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin." J Nanobiotechnology. 2022 May 14;20(1):230. PMID: 35568865
2. Liyuan Zou, Xiaokun Ma, et al. "Protective Effect of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on Cardiomyoblast Hypoxia-Reperfusion Injury Through the miR-149/let-7c/Faslg Axis." Free Radic Res. 2020 Oct;54(10):722-731. PMID: 33054503

Chemical Properties

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	652.23
Cas No.	3520-43-2
Formula	C₂₅H₂₇Cl₄IN₄
Synonyms	CBIC2;JC1;JC 1
Solubility	≥32.6 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
Chemical Name	5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole;iodide
SDF	Download SDF
Canonical SMILES	CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-]
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 98.00%

Chemical structure

Related Biological Data

JC-1 [3520-43-2]

Referentie A3516-5mg

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