KCC2 Antibody
Referentie OASE00240
Formaat : 100ug
Merk : Aviva Systems Biology
Neem contact op met een lokale distributeur :
Telefoonnummer : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for OASE00240 |
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| Predicted Species Reactivity | Human, Mouse, Rat |
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| Product Format | Liquid. PBS (pH 7.4) with 50% glycerol and 0.09% sodium azide. |
| Clonality | Monoclonal |
| Clone | S1-12 |
| Isotype | IgG2a |
| Host | Mouse |
| Conjugation | Unconjugated |
| Application | WB, IHC, ICC, IF, IP |
| Additional Information | Cellular Localization: Membrane |
| Reconstitution and Storage | Store at -20C. Shipping with Blue Ice or 4C. |
| Immunogen | Fusion protein amino acids 932-1043 corresponding to rat KCC2 |
| Purification | Protein G Purified |
| Concentration | 1 mg/ml |
| Specificity | Detects ~140kDa. |
| Dilution | WB (1:1000), IHC (1:300), ICC/IF (1:100); optimal dilutions for assays should be determined by the user. |
| Application Info | WB: 1:1000 IHC: 1:300 ICC: 1:100 IF: 1:100 Optimal dilutions should be determined by the end user. |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Publications | Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model. Dev Neurobiol. 78, 1117-1130 (2018). 30136373 TrkB agonists prevent postischemic emergence of refractory neonatal seizures in mice. JCI Insight. 5, NULL (2020). 32427585 |
| Description |
| Reference | 1. Lee L.H., Walker J.A., Williams J.R., Goodier R.J., Payne J.A., Moss S.J. (2007) J Biol Chem. 282(41): 29777-29784. 2. Watanabe M., Wake H., Moorhouse A.J., Nabekura J. (2009) J Biol Chem. 284(41): 27980-27988. 3. Gulyas A.I., Sik A., Payne J.A., Kaila K., Freund T.F. (2001) Eur J Neurosci. 13(12): 2205-2217. 4. Vinay L., Jean-Xavier C. (2008) Brain Res Rev. 57(1): 103-110. |
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| Gene Symbol | KCC2 |
| Gene Full Name | solute carrier family 12 (potassium-chloride transporter), member 5 |
| Alias Symbols | Potassium Chloride Cotransporter, Potassium chloride transporter 5, SLC12A5, hKCC2, S12A5, Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, Furosemide-sensitive K-Cl cotransporter, K-Cl cotransporter 2, rKCC2, Neuronal K-Cl cotransporter, KIAA1176, Electroneutral potassium chloride cotransporter 2, Erythroid K Cl cotransporter 2, Furosemide sensitive K Cl cotransporter, K-Cl cotransporter 2, KCC 2, Neuronal K Cl cotransporter, Solute carrier family 12 (potassium chloride transporter) member 5, Solute carrier family 12 member 5 |
| NCBI Gene Id | 171373 |
| Description of Target | KCC2 is a member of the cation-chloride cotransporter gene family. It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain. KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior. |
| Uniprot ID | Q63633 |
| Protein Accession # | NP_599190 |
| Molecular Weight | 140 kDa |
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What is the species homology for "KCC2 Antibody (OASE00240)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".
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How long will it take to receive "KCC2 Antibody (OASE00240)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "KCC2 Antibody (OASE00240)" provided in?
This item is provided in "Liquid. PBS (pH 7.4) with 50% glycerol and 0.09% sodium azide.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "KCC2 Antibody (OASE00240)"?
This target may also be called "Potassium Chloride Cotransporter, Potassium chloride transporter 5, SLC12A5, hKCC2, S12A5, Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, Furosemide-sensitive K-Cl cotransporter, K-Cl cotransporter 2, rKCC2, Neuronal K-Cl cotransporter, KIAA1176, Electroneutral potassium chloride cotransporter 2, Erythroid K Cl cotransporter 2, Furosemide sensitive K Cl cotransporter, K-Cl cotransporter 2, KCC 2, Neuronal K Cl cotransporter, Solute carrier family 12 (potassium chloride transporter) member 5, Solute carrier family 12 member 5" in publications.
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What is the shipping cost for "KCC2 Antibody (OASE00240)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
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What is the guarantee for "KCC2 Antibody (OASE00240)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "KCC2 Antibody (OASE00240)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "140 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "KCC2 Antibody (OASE00240)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "KCC2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "KCC2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "KCC2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "KCC2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "KCC2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "KCC2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.