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Kinetin triphosphate (tetrasodium)

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Referentie HY-134398A-5mg

Formaat : 5mg

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Telefoonnummer : +1 850 650 7790

Merk : MedChemExpress

Neem contact op met een lokale distributeur :

Telefoonnummer : +1 850 650 7790

Kinetin triphosphate(6-Fu-ATP) tetrasodium is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate tetrasodium can be used in Parkinson's disease research.

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Kinetin triphosphate tetrasodium Chemical Structure

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Other Forms of Kinetin triphosphate tetrasodium:

Kinetin triphosphate Obtenir un devis

Description

In Vitro

Kinetin triphosphate tetrasodium can act as a phosphate donor for PINK1 to recognize the T257 autophosphorylation site, and can restore the catalytic activity of PINK1 G309D to close to WT levels in HeLa cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

675.19

Formule

C₁₅H₁₆N₅Na₄O₁₄P₃

Appearance

Solid

Color

White to off-white

SMILES

O=P(O[Na])(O[Na])OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(NCC4=CC=CO4)=C3N=C2)[C@H](O)[C@@H]1O)(O[Na])=O)(O[Na])=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

H₂O : 250 mg/mL (370.27 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4811 mL	7.4053 mL	14.8106 mL
5 mM	0.2962 mL	1.4811 mL	2.9621 mL
10 mM	0.1481 mL	0.7405 mL	1.4811 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Nicholas T Hertz, et al. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 2013 Aug 15;154(4):737-47. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4811 mL	7.4053 mL	14.8106 mL	37.0266 mL
	5 mM	0.2962 mL	1.4811 mL	2.9621 mL	7.4053 mL
	10 mM	0.1481 mL	0.7405 mL	1.4811 mL	3.7027 mL
	15 mM	0.0987 mL	0.4937 mL	0.9874 mL	2.4684 mL
	20 mM	0.0741 mL	0.3703 mL	0.7405 mL	1.8513 mL
	25 mM	0.0592 mL	0.2962 mL	0.5924 mL	1.4811 mL
	30 mM	0.0494 mL	0.2468 mL	0.4937 mL	1.2342 mL
	40 mM	0.0370 mL	0.1851 mL	0.3703 mL	0.9257 mL
	50 mM	0.0296 mL	0.1481 mL	0.2962 mL	0.7405 mL
	60 mM	0.0247 mL	0.1234 mL	0.2468 mL	0.6171 mL
	80 mM	0.0185 mL	0.0926 mL	0.1851 mL	0.4628 mL
	100 mM	0.0148 mL	0.0741 mL	0.1481 mL	0.3703 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.