LAMP-1 Polyclonal Antibody, PE-Cy5 Conjugated
Referentie bs-1970R-PE-Cy5
Formaat : 100ul
Merk : Bioss
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Telefoonnummer : +1 850 650 7790
LAMP-1 Polyclonal Antibody, PE-Cy5 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-1970R-PE-Cy5 |
| Product Name | LAMP-1 Polyclonal Antibody, PE-Cy5 Conjugated |
| Applications | WB, FCM |
| Reactivity | Human, Mouse, Rat, Monkey |
| Specifications | |
| Conjugation | PE-Cy5 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human LAMP-1 |
| Immunogen Range | 301-417/417 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 3916 |
| Swiss Prot | P11279 |
| Subcellular location | Cytoplasm, Cell membrane |
| Synonyms | LAMPA; CD17a; LGP12; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD17 antigen-like family member A; LAMP1 |
| Background | Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |