Leflunomide
Referentie M2229-200mg
Formaat : 200mg
Merk : AbMole Bioscience
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HWA486; RS-34821; SU101
Quality Control & Documentation
Biological Activity
Leflunomide is an inhibitor of dihydroorotate dehydrogenase with IC50 of 2.5 μM. Leflunomide inhibits de novo pyrimidine synthesis in human T-cells in vitro. Leflunomide also inhibits lymphocyte proliferation. The inhibition of human DHODH by A77 1726, the active metabolite of leflunomide, occurs at levels (approximately 600 nM) that are achieved during treatment of rheumatoid arthritis (RA).
Chemical Information
| Molecular Weight | 270.21 |
| Formula | C12H9F3N2O2 |
| CAS Number | 75706-12-6 |
| Solubility (25°C) | DMSO 40 mg/mL Ethanol 10 mg/mL |
| Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Davis JP, et al. Biochemistry. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase.
[2] Xu X, et al. J Biol Chem. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide.