Application
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9Y5Y7 |
| Other Accession | Q6UC88, NP_006682 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35213 Da |
| Antigen Region | 243-272 aa |
| Gene ID | 10894 |
|---|---|
| Other Names | Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, LYVE1, CRSBP1, HAR, XLKD1 |
| Target/Specificity | This LYVE1 (XLKD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the C-terminal region of human LYVE1 (XLKD1). |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LYVE1 (XLKD1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LYVE1 |
|---|---|
| Synonyms | CRSBP1, HAR, XLKD1 |
| Function | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans- Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface Localizes at cell-cell junctions |
| Tissue Location | Mainly expressed in endothelial cells lining lymphatic vessels. |
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Provided below are standard protocols that you may find useful for product applications.
Background
XLKD1 is a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.
References
Jackson, D.G., Trends Cardiovasc. Med. 13(1):1-7 (2003). Cursiefen, C., et al., Invest. Ophthalmol. Vis. Sci. 43(7):2127-2135 (2002). Cunnick, G.H., et al., Biochem. Biophys. Res. Commun. 288(4):1043-1046 (2001). Mouta Carreira, C., et al., Cancer Res. 61(22):8079-8084 (2001). Banerji, S., et al., J. Cell Biol. 144(4):789-801 (1999).