Mouse Anti-Human CD55-FITC

Referentie 9661-02S

Formaat : 25tests

Merk : Southern Biotech

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Telefoonnummer : +1 850 650 7790

More Information
Clone 143-30
Isotype Mouse IgG1κ
Isotype Control Mouse IgG1-FITC (15H6)
Specificity Human CD55
Alternative Names DAF, decay accelerating factor
Description CD55, also known as decay accelerating factor (DAF), is an 80 kDa GPI-anchored single chain glycoprotein that is expressed on all cells in contact with serum including all hematopoietic cells and the vascular endothelium. A soluble form of CD55 is present in plasma and body fluids. CD55 is a member of the regulator of complement activity (RCA) family of proteins and is thought to play a role in the protection of cells from damage by autologous complement by preventing the amplification steps of the complement cascade. CD55 expression increases upon T cell activation and antibodies to CD55 are mitogenic in the presence of phorbol esters.
Immunogen PHA activated peripheral blood mononuclear cells
Conjugate FITC (Fluorescein)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration Lot specific
Volume 0.25 mL or 1.0 mL
Recommended Storage 2-8°C; Avoid exposure to light
Applications Flow Cytometry – Quality tested 5,6
Immunohistochemistry-Frozen Sections – Reported in literature 1
Immunohistochemistry-Paraffin Sections – Reported in literature 2
Immunoprecipitation – Reported in literature 3
Western Blot-Non-Reducing – Reported in literature 4

RRID Number AB_2797048
Gene ID 1604 (Human)
Gene ID Symbol CD55 (Human)
Gene ID Aliases CR; TC; DAF; CROM; CHAPLE
UniProt ID P08174 (Human
UniProt Name DAF_HUMAN (Human)
Documentation
Technical Bulletin Safety Datasheet

Certificate of Analysis Lookup

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  1. 1. Koretz K, Brüderlein S, Henne C, Möller P. Decay-accelerating factor (DAF, CD55) in normal colorectal mucosa, adenomas and carcinomas. Br J Cancer. 1992;66:810-4. (IHC-FS)
  2. 2. Wu J, Lei L, Wang S, Gu D, Zhang J. Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma. J Biomed Biotechnol. 2012;2012:587672. (IHC-PS)
  3. 3. Stefanová I, Hořejší V, Ansotegui IJ, Knapp W, Stockinger H. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science. 1991;254:1016-9. (IP)
  4. 4. Clayton A, Harris CL, Court J, Mason MD, Morgan BP. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur J Immunol. 2003;33:522-31. (WB)
  5. 5. Zeuke S, Ulmer A, Kusumoto S, Katus HA, Heine H. TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS. Cardiovasc Res. 2002;56:126-34. (FC)
  6. 6. Haas P, Aggermann T, Nagl M, Steindl-Kuscher K, Krugluger W, Binder S. Implication of CD21, CD35, and CD55 in the pathogenesis of age-related macular degeneration. Am J Ophthalmol. 2011;152:396-9. (FC)