Mouse Monoclonal Anti-CD11b / MAC-1 (Microglial Marker) [Clone ITGAM/271]
Referentie NB-36-00374-P0
Formaat : 20ug
Merk : Neo Biotech
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CD11b / MAC-1 (Microglial Marker) Antibody [ITGAM/271]
SDS-PAGE Analysis of Purified CD11b Mouse Monoclonal Antibody (ITGAM/271). Confirmation of Integrity and Purity of Antibody.
Applications & Dilutions
Summary
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin aM combines with the Integrin '2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin aM/'2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b andCD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.
Product Properties & Targets
Functions
- Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).
Key References
- Springer T, et al. 1978. Eur. J. Immunol. 8:539.
- Ault K and Springer T. 1981. J. Immunol. 126:359.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/2457584/
- https://pubmed.ncbi.nlm.nih.gov/2833753/
- https://pubmed.ncbi.nlm.nih.gov/2454931/
- https://pubmed.ncbi.nlm.nih.gov/8419480/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/2563162/
- https://pubmed.ncbi.nlm.nih.gov/1683702/
- https://pubmed.ncbi.nlm.nih.gov/1346576/
- https://pubmed.ncbi.nlm.nih.gov/3539202/
- https://pubmed.ncbi.nlm.nih.gov/9558116/
- https://pubmed.ncbi.nlm.nih.gov/12208882/
- https://pubmed.ncbi.nlm.nih.gov/15194813/
- https://pubmed.ncbi.nlm.nih.gov/19159218/
- https://pubmed.ncbi.nlm.nih.gov/20008295/
- https://pubmed.ncbi.nlm.nih.gov/21193407/
- https://pubmed.ncbi.nlm.nih.gov/27055590/
- https://pubmed.ncbi.nlm.nih.gov/28807980/
- https://pubmed.ncbi.nlm.nih.gov/7867070/
- https://pubmed.ncbi.nlm.nih.gov/8747460/
- https://pubmed.ncbi.nlm.nih.gov/9687375/
- https://pubmed.ncbi.nlm.nih.gov/9560195/
- https://pubmed.ncbi.nlm.nih.gov/18204448/
- https://pubmed.ncbi.nlm.nih.gov/18204446/
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