Periplocymarin [32476-67-8]
Referentie HY-N4252-10mg
Formaat : 10mg
Merk : MedChemExpress
Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound.
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Periplocymarin Chemical Structure
CAS No. : 32476-67-8
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound[1][2]. |
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In Vitro |
Periplocymarin inhibits proliferation of PC3, U937, HCT-8, Bel-7402, BGC823, A549, and A2780 cell lines in vitro with IC50 values of 0.02-0.29 µM[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Masse moléculaire |
534.68 |
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Formule |
C30H46O8 |
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CAS No. |
32476-67-8 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O[C@@]12[C@@]3(09)[C@@](CC[C@@]1([C@@H](C4=CC(OC4)=O)CC2)C)(09)[C@@]5([C@@](O)(C[C@@H](O[C@@]6(09)C[C@@H]([C@H](O)[C@@H](C)O6)OC)CC5)CC3)C |
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Structure Classification |
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Initial Source |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvant et solubilité |
In Vitro:
DMSO : 100 mg/mL (187.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.8703 mL | 9.3514 mL | 18.7028 mL | 46.7569 mL |
5 mM | 0.3741 mL | 1.8703 mL | 3.7406 mL | 9.3514 mL | |
10 mM | 0.1870 mL | 0.9351 mL | 1.8703 mL | 4.6757 mL | |
15 mM | 0.1247 mL | 0.6234 mL | 1.2469 mL | 3.1171 mL | |
20 mM | 0.0935 mL | 0.4676 mL | 0.9351 mL | 2.3378 mL | |
25 mM | 0.0748 mL | 0.3741 mL | 0.7481 mL | 1.8703 mL | |
30 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5586 mL | |
40 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1689 mL | |
50 mM | 0.0374 mL | 0.1870 mL | 0.3741 mL | 0.9351 mL | |
60 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7793 mL | |
80 mM | 0.0234 mL | 0.1169 mL | 0.2338 mL | 0.5845 mL | |
100 mM | 0.0187 mL | 0.0935 mL | 0.1870 mL | 0.4676 mL |