A1018-25mg | Platelet Membrane Glycoprotein IIB Peptide (296-306)

Background

Human alloantisera specific for either the Bak' or Bakb allele have been shown to react exclusively with the heavy chain of membrane glycoprotein (GP) Ilb.

GPllb is composed of a 125 Kd heavy chain that is disulfide-linked to a 23 Kd light chain. Hydropathicity analysis of the cDNA sequence indicates that GPllb is anchored to the platelet through a single transmembrane domain located within 20 amino acids of the C-terminus of the light chain.

The GPllb-IIa complex is a Ca²⁺-dependent heterodimer that, on activated platelets, can bind one of the four different adhesive proteins. (i.e. fibrinogen, fibronectin, von Willebrand factor, or vitronectin ).

Ref:

1. Bray PF, Rosa J-P, Lingappa VR, Kan YW, McEver RP, Shuman MA: Biogenesis of the platelet receptor for fibrinogen: Evidence for separate precursors for glycoproteins Ilb and IIIa. Proc Natl Acad Sci USA 83:1480,1986

2. Silver SM, McDonough MM, Vilaire G, Bennett JS: The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa. Blood 69:1031, 1987.

3. Phillips DR, Charo IF, Parise LV, Fitzgerald LA : The platelet membrane glycoproteins IIb-IIIa co,plex. Blood 71:831-843, 1988

Product Citation

1. Feng Wang, Kai-Rui Feng, et al. "Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study." Bioorg Med Chem. 2020 Oct 22;28(24):115822. PMID: 33126089

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	1198.2
Formula	C₄₇H₇₅N₁₇O₂₀
Synonyms	H2N-Thr-Asp-Val-Asn-Gly-Asp-Gly-Arg-His-Asp-Leu-OH
Solubility	≥119.8 mg/mL in DMSO; ≥5 mg/mL in EtOH with ultrasonic; ≥50 mg/mL in H2O
SDF	Download SDF
Canonical SMILES	N[C@@H]([C@H](C)O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 98.92%

Platelet Membrane Glycoprotein IIB Peptide (296-306)

Referentie A1018-25mg

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Background

Product Citation

Chemical Properties

Quality Control