PrP (6G3)
Referentie sc-52969
Formaat : 50µg/0.5ml
Merk : Santa Cruz Biotechnology
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Telefoonnummer : +1 850 650 7790
Anticorps PrP (6G3): sc-52969
- L'anticorps PrP 6G3 est un monoclonal IgG1 de souris fourni en 50 µg/0.5 ml
- dirigé contre les acides aminés 130-150 de d'origine human
- recommandé pour la détection de PrP d'origine mouse, rat, human, bovine, ovine et deer par WB et IP
- and Cruz Marker™ MW Standards Promotional
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Characteristic of prion diseases, cellular PrP (PrPc) is converted to the disease form, PrPSc, through alterations in the protein folding conformations. PrPc is constitutively expressed in normal adult brain and is sensitive to proteinase K digestion, while the altered PrPSc conformation is resistant to proteases, resulting in a distinct molecular mass after PK treatment. Consistent with the transient infection process of prion diseases, incubation of PrPc with PrPSc both in vitro and in vivo produces PrPc that is resistant to protease degradation. Infectious PrPSc is found at high levels in the brains of animals affected by TSEs, including scrapie in sheep, BSE in cattle and Cruetzfeldt-Jakob disease in humans.
| Espèces | Nom du Gène | Gene ID | Localisation chromosomique | Numéro d'accession de l'isoforme (ARNm) | Numéro d'accès aux protéines | Numéro OMIM™ |
|---|---|---|---|---|---|---|
| Human | PRNP | Entrez Gene ID: 5621 | 20p13 | NM_000311, NM_001080121, NM_001080122, NM_001080123, NM_001271561, NM_183079 | UniProt ID: F7VJQ1 | 606688 |
| Mouse | Prnp | Entrez Gene ID: 19122 | 2 F2 | NM_001278256, NM_011170 | UniProt ID: P04925 | N/A |
L'anticorps PrP préféré est l'Anticorps PrP (8B4): sc-47729.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PrP (6G3) | sc-52969 | 50 µg/0.5 ml | .00 |
I am using PrP (6G3): sc-52969 antibody for immunoprecipitation, how much antibody should I use?
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