CE25-500ug | Recombinant Human B-Cell Linker Protein/BLNK (C-6His)

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Certificate of Analysis

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Endotoxin

Accession Number

AAH18906

Species

Human

Expression System

E.coli

Target Sequence

Met1-Ser456

C-His

Formulation

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.

Packaging

Ambient

Background

B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.

Purity

Greater than 90% as determined by reducing SDS-PAGE.

B-Cell Linker Protein; B-Cell Adapter Containing a SH2 Domain Protein; B-Cell Adapter Containing a Src Homology 2 Domain Protein; Cytoplasmic Adapter Protein; Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa; SLP-65; BLNK; BASH; SLP65

Recombinant Human B-Cell Linker Protein/BLNK (C-6His)

Referentie CE25-500ug

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Merk : Bon Opus Biosciences