Recombinant Mouse IFN-beta Protein (HEK293)

Biological Activity

Interferon-beta (IFN beta) is an extracellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative, and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis.

Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 3-18 pg/mL.

The recombinant mouse IFNB1 consists of 166 amino acids and has a calculated molecular mass of 20.3 kDa.

Lyophilized from sterile PBS, pH 7.4.

Chemical Information

Solubility (25°C)	Reconstitute the lyophilized powder in ddH2O to 250 μg/ml
Storage	Stable for up to twelve months from date of receipt at -20℃ to -80℃

References

[1] Kara J Mould, et al. Am J Respir Cell Mol Biol. Recombinant IFN-β for Postseptic Acute Lung Injury-What's the Mechanism?

[2] Leticia Corrales, et al. Cell Rep. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

[3] Lingyin Li, et al. Nat Chem Biol. Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs

[4] Campbell Kaynor, et al. J Interferon Cytokine Res. Direct evidence that IFN-beta functions as a tumor-suppressor protein

[5] M A Horisberger, et al. Pharmacol Ther. Interferon-alpha hybrids