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Interferon-gamma (IFN-gamma) is a pleotropic cytokine expressed predominantly by naïve and activated CD8+ and TH1 CD4+ T cells, and natural killer (NK) cells and, as such, promotes both innate and adaptive immune responses.
The activity of IFN-gamma is mediated through its receptor, the high-affinity IFN-gamma receptor complex, a class II cytokine receptor that is present on T cells, B cells, macrophages, neutrophils and NK cells as well as non-immune somatic cells such as endothelial cells and fibroblasts. The high-affinity IFN-gamma receptor complex comprises two different subunits, the alpha (IFN-gamma R1, CDw119) and beta (IFN-gamma R2) subunits.
| The IFN-gamma R2 subunit is a 310 amino acid (~35 kDa) type I membrane protein that contains two fibronectin type III domains and six potential N-linked glycosylation sites and is involved in signal transduction. |
For a review on Type I Interferons please refer to Oritani et al., (2001) Cytokine Growth Factor Rev. 12(4): 337-48.
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