ROCK inhibitor-2 [1127308-52-4]
Referentie HY-119937-1ml
Formaat : 10mM/1mL
Merk : MedChemExpress
ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC50 of 75 nM. ROCK inhibitor-2 exhibits antitumor activity.
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ROCK inhibitor-2 Chemical Structure
CAS No. : 1127308-52-4
Size | Prix | Stock | Quantité |
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Échantillon gratuit (0.1 - 0.5 mg) | Appliquer maintenant | ||
Solid + Solvent (Highly Recommended) | |||
10 mM * 1 mL
in DMSO
ready for reconstitution
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En stock | ||
Solution | |||
10 mM * 1 mL in DMSO | En stock | ||
Solid | |||
5 mg | En stock | ||
10 mg | En stock | ||
25 mg | En stock | ||
50 mg | En stock | ||
100 mg | En stock | ||
200 mg | Obtenir un devis | ||
500 mg | Obtenir un devis |
* Veuillez sélectionner la quantité avant d'ajouter des articles.
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Description |
ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC50 of 75 nM. ROCK inhibitor-2 exhibits antitumor activity[1][2]. |
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IC50 & Target[1] |
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In Vitro |
ROCK inhibitor-2 (50 μM, 24-48 h) reduces the formation of cell-in-cell structure in cell U2OS, inhibits the cell migration and invasion of U2OS, and leads to mitochondrial dysfunction[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Migration Assay [2]
Western Blot Analysis[2]
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In Vivo |
ROCK inhibitor-2 (10 mg/kg*day, ip, 27 days) exhibits antitumor efficacy in U2OS xenograft mouse models[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Masse moléculaire |
332.40 |
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Formule |
C21H20N2O2 |
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CAS No. |
1127308-52-4 |
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Appearance |
Solid |
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Color |
White to light yellow |
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SMILES |
O=C(N[C@H](C)C1=CC=CC(OC)=C1)C(C=C2)=CC=C2C3=CC=NC=C3 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 200 mg/mL (601.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation |
Purity: 99.92%
SDS (251 KB)
COA (245 KB) HNMR (259 KB) RP-HPLC (159 KB) LCMS (374 KB) Instruction de manipulation (2659 KB) |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.0084 mL | 15.0421 mL | 30.0842 mL | 75.2106 mL |
5 mM | 0.6017 mL | 3.0084 mL | 6.0168 mL | 15.0421 mL | |
10 mM | 0.3008 mL | 1.5042 mL | 3.0084 mL | 7.5211 mL | |
15 mM | 0.2006 mL | 1.0028 mL | 2.0056 mL | 5.0140 mL | |
20 mM | 0.1504 mL | 0.7521 mL | 1.5042 mL | 3.7605 mL | |
25 mM | 0.1203 mL | 0.6017 mL | 1.2034 mL | 3.0084 mL | |
30 mM | 0.1003 mL | 0.5014 mL | 1.0028 mL | 2.5070 mL | |
40 mM | 0.0752 mL | 0.3761 mL | 0.7521 mL | 1.8803 mL | |
50 mM | 0.0602 mL | 0.3008 mL | 0.6017 mL | 1.5042 mL | |
60 mM | 0.0501 mL | 0.2507 mL | 0.5014 mL | 1.2535 mL | |
80 mM | 0.0376 mL | 0.1880 mL | 0.3761 mL | 0.9401 mL | |
100 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.7521 mL |
ROCK inhibitor-2 Related Classifications
- Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
- ROCK
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Keywords:
ROCK inhibitor-21127308-52-4ROCK inhibitor2ROCK inhibitor 2ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKpMYPT1Inhibitorinhibitorinhibit