RUNX1 + RUNX2 Polyclonal Antibody, FITC Conjugated
Referentie bs-1134R-FITC
Formaat : 100ul
Merk : Bioss
RUNX1 + RUNX2 Polyclonal Antibody, FITC Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-1134R-FITC |
Product Name | RUNX1 + RUNX2 Polyclonal Antibody, FITC Conjugated |
Applications | WB, FCM, IF(IHC-P), IF(IHC-F), IF(ICC) |
Reactivity | Human, Mouse, Rat, Rabbit, Guinea Pig |
Predicted Reactivity | Dog, Cow, Sheep, Horse, Chicken |
Specifications | |
Conjugation | FITC |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human RUNX2 |
Immunogen Range | 202-300/521 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 860 |
Swiss Prot | Q13950 |
Subcellular location | Nucleus |
Synonyms | CCD; AML3; CCD1; CLCD; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2aA; CBF-alpha-1; Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; RUNX2; PEBP2A |
Background | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. |
Application Dilution | |
WB | 1:300-5000 |
FCM | 1:20-100 |
IF(IHC-P) | 1:50-200 |
IF(IHC-F) | 1:50-200 |
IF(ICC) | 1:50-200 |