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> Ruxolitinib phosphate

Ruxolitinib phosphate

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Referentie M5944-10mg

Formaat : 10mg

Merk : AbMole Bioscience

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Telefoonnummer : +1 850 650 7790

All AbMole products are for research use only, cannot be used for human consumption.

Ruxolitinib phosphate Structure
Synonym:

INCB018424 phosphate; INCB 018424 phosphate; INCB-018424 phosphate; Ruxolitinib

Quality Control & Documentation
Biological Activity

Ruxolitinib phosphate(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.

Product Citations

  • J Virol. 2020 Feb 14;94(5):e01791-19.

    Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use
    Ruxolitinib phosphate purchased from AbMole

Chemical Information
Molecular Weight 404.36
Formula C17H21N6O4P
CAS Number 1092939-17-7
Solubility (25°C) DMSO ≥ 30 mg/mL
Water 8.2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chen X, et al. Clin Pharmacol Drug Dev. Pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in renal and hepatic impairment patients.