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> S-Hexylglutathione [24425-56-7]

S-Hexylglutathione [24425-56-7]

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Referentie HY-W013754-10mg

Formaat : 10mg

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S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase and glutathione peroxidase.

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S-Hexylglutathione Chemical Structure

S-Hexylglutathione Chemical Structure

CAS No. : 24425-56-7

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Description

S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase and glutathione peroxidase[1][2].

In Vitro

S-Hexylglutathione is bound by human glutathione transferase P1-1 with Kd values of 3.7 μM (Y49F mutant) and 1.27 μM (wild-type), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-Hexylglutathione Related Antibodies
Masse moléculaire

391.48

Formule

C16H29N3O6S
CAS No.

24425-56-7
Appearance

Solid

Color

White to yellow

SMILES

OC(CNC([C@H](CSCCCCCC)NC(CC[C@H](N)C(O)=O)=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 12.5 mg/mL (31.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5544 mL 12.7720 mL 25.5441 mL
5 mM 0.5109 mL 2.5544 mL 5.1088 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Pureté et documentation

Purity: 99.94%

SDS (393 KB)

COA (244 KB) RP-HPLC (109 KB) MS (204 KB)

Instruction de manipulation (2659 KB)
Références

  • [1]. Ortiz-Salmerón E, et al. Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione. J Biol Chem. 2003 Nov 21;278(47):46938-48.  [Content Brief]

    [2]. Swope MD, et al. Macrophage migration inhibitory factor interactions with glutathione and S-hexylglutathione. J Biol Chem. 1998 Jun 12;273(24):14877-84.  [Content Brief]

  • [1]. Ortiz-Salmerón E, et al. Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione. J Biol Chem. 2003 Nov 21;278(47):46938-48.

    [2]. Swope MD, et al. Macrophage migration inhibitory factor interactions with glutathione and S-hexylglutathione. J Biol Chem. 1998 Jun 12;273(24):14877-84.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5544 mL 12.7720 mL 25.5441 mL 63.8602 mL
5 mM 0.5109 mL 2.5544 mL 5.1088 mL 12.7720 mL
10 mM 0.2554 mL 1.2772 mL 2.5544 mL 6.3860 mL
15 mM 0.1703 mL 0.8515 mL 1.7029 mL 4.2573 mL
20 mM 0.1277 mL 0.6386 mL 1.2772 mL 3.1930 mL
25 mM 0.1022 mL 0.5109 mL 1.0218 mL 2.5544 mL
30 mM 0.0851 mL 0.4257 mL 0.8515 mL 2.1287 mL
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S-Hexylglutathione Related Classifications

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Keywords:

S-Hexylglutathione24425-56-7Othersglutathionehexyl groupthiolcompetitiveInhibitorinhibitorinhibit