Sulfaguanidine
Referentie M3038-200mg
Formaat : 200mg
Merk : AbMole Bioscience
Quality Control & Documentation
Biological Activity
Sulfaguanidine is a sulfonamide used as an anti-infective agent.
Chemical Information
Molecular Weight | 214.24 |
Formula | C7H10N4O2S |
CAS Number | 57-67-0 |
Form | Solid |
Solubility (25°C) | DMSO 30 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Hemat M Dardeer, et al. Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO 2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine
[2] Ahmed Ragab, et al. Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors
[3] S. Russ Richardson, et al. Glucose 6 Phosphate Dehydrogenase Deficiency
[4] Syed Sibte Asghar Abidi, et al. Sulfaguanidine cocrystals: Synthesis, structural characterization and their antibacterial and hemolytic analysis
[5] C A Hoppert. SULFAGUANIDINE OR SULFA-AMIDINE?