OPSA10541 | SYNTHETIC Human INSULIN B CHAIN Protein Clinisciences

Datasheets/Manuals	Printable datasheet for OPSA10541

Product Info
Predicted Species Reactivity	Human
Product Format	Liquid Trifluoroacetate salt
Application	ELISA
Reconstitution and Storage	Store at -20C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate, microcentrifuge before use. Shelf Life: 18 months from date of dispatch.
Purification	Solid phase synthesis
Concentration	2.0 mg/ml (total protein concentration)
Purity	HPLC: >95%

Gene Symbol	INS
Alias Symbols	IDDM, ILPR, IRDN, IDDM1, IDDM2, PNDM4, MODY10
NCBI Gene Id	3630
Protein Name	Insulin
Uniprot ID	P01308
Protein Accession #	NP_000198.1
Protein Size (# AA)	110
Molecular Weight	585 Da

Protein interactions

Name	# of Products
CPE	74
CTSB	172
CTSD	128
CTSE	48
GCK	49
HLA-DQA2	38
HLA-DQB1	40
IDE	57
IGF1R	168
IGFBP7	103
INS	95
INSR	215
LRP2	188
MAPK6	386
MLL	163
NOV	80
RB1	474
SYTL4	52
TXNDC17	48

Biological pathways

Name	# of Products
Activation of protein kinase B activity	71
Acute-phase response	209
Alpha-beta T cell activation	30
Cell-cell signaling	763
Endocrine pancreas development	246
Energy reserve metabolic process	196
Fatty acid homeostasis	46
Fibroblast growth factor receptor signaling pathway	279
Glucose homeostasis	196
Glucose metabolic process	196
Glucose transport	103
G-protein coupled receptor signaling pathway	315
Insulin receptor signaling pathway	491
MAPKKK cascade	71
Negative regulation of acute inflammatory response	40
Negative regulation of apoptotic process	538
Negative regulation of fatty acid metabolic process	31
Negative regulation of feeding behavior	30
Negative regulation of gluconeogenesis	58
Negative regulation of glycogen catabolic process	30
Negative regulation of lipid catabolic process	87
Negative regulation of NAD(P)H oxidase activity	32
Negative regulation of protein catabolic process	96
Negative regulation of protein secretion	37
Negative regulation of proteolysis	59
Negative regulation of respiratory burst involved in inflammatory response	30
Negative regulation of vasodilation	31
Positive regulation of cell differentiation	61
Positive regulation of cell growth	178
Positive regulation of cell migration	287
Positive regulation of cell proliferation	582
Positive regulation of cytokine secretion	124
Positive regulation of DNA replication	222
Positive regulation of glucose import	149
Positive regulation of glycogen biosynthetic process	109
Positive regulation of glycolysis	82
Positive regulation of insulin receptor signaling pathway	45
Positive regulation of lipid biosynthetic process	61
Positive regulation of MAPKKK cascade	189
Positive regulation of mitosis	179
Positive regulation of NF-kappaB transcription factor activity	346
Positive regulation of nitric oxide biosynthetic process	220
Positive regulation of nitric-oxide synthase activity	101
Positive regulation of peptidyl-tyrosine phosphorylation	308
Positive regulation of phosphatidylinositol 3-kinase cascade	210
Positive regulation of protein autophosphorylation	71
Positive regulation of protein kinase B signaling cascade	183
Positive regulation of respiratory burst	43
Positive regulation of vasodilation	48
Regulation of cellular amino acid metabolic process	134
Regulation of insulin secretion	182
Regulation of transmembrane transporter activity	40
Wound healing	105

Biological process

Name	# of Products
Activation of protein kinase B activity	12
Acute-phase response	48
Alpha-beta T cell activation	2
Carbohydrate metabolic process	247
Cell-cell signaling	235
Endocrine pancreas development	50
Energy reserve metabolic process	72
Fatty acid homeostasis	11
Glucose homeostasis	77
Glucose metabolic process	107
Glucose transport	63
G-protein coupled receptor signaling pathway	262
Insulin receptor signaling pathway	146
MAPK cascade	105
Negative regulation of acute inflammatory response	9
Negative regulation of apoptotic process	356
Negative regulation of fatty acid metabolic process	4
Negative regulation of feeding behavior	2
Negative regulation of gluconeogenesis	11
Negative regulation of glycogen catabolic process	3
Negative regulation of lipid catabolic process	21
Negative regulation of NAD(P)H oxidase activity	3
Negative regulation of protein catabolic process	22
Negative regulation of protein secretion	8
Negative regulation of proteolysis	21
Negative regulation of respiratory burst involved in inflammatory response	3
Negative regulation of vasodilation	3
Positive regulation of cell differentiation	38
Positive regulation of cell growth	70
Positive regulation of cell migration	150
Positive regulation of cell proliferation	483
Positive regulation of cellular protein metabolic process	20
Positive regulation of cytokine secretion	38
Positive regulation of DNA replication	56
Positive regulation of glucose import	34
Positive regulation of glycogen biosynthetic process	23
Positive regulation of glycolysis	15
Positive regulation of insulin receptor signaling pathway	10
Positive regulation of lipid biosynthetic process	8
Positive regulation of MAPK cascade	81
Positive regulation of mitosis	50
Positive regulation of NF-kappaB transcription factor activity	135
Positive regulation of nitric oxide biosynthetic process	53
Positive regulation of nitric-oxide synthase activity	14
Positive regulation of peptidyl-tyrosine phosphorylation	112
Positive regulation of phosphatidylinositol 3-kinase cascade	60
Positive regulation of protein autophosphorylation	18
Positive regulation of protein kinase B signaling cascade	61
Positive regulation of respiratory burst	5
Positive regulation of vasodilation	16
Regulation of cellular amino acid metabolic process	45
Regulation of insulin secretion	77
Regulation of protein localization	26
Regulation of protein secretion	14
Regulation of transcription, DNA-dependent	1734
Regulation of transmembrane transporter activity	3
Small molecule metabolic process	825
Wound healing	86

Cellular components

Name	# of Products
Endoplasmic reticulum lumen	87
Endosome lumen	5
Extracellular region	1573
Extracellular space	884
Golgi lumen	35
Secretory granule	77

Protein function

Name	# of Products
Hormone activity	494
Insulin receptor binding	129
Insulin-like growth factor receptor binding	112
Protein binding	12191

Diseases

Name	# of Products
Diabetes mellitus	299
Disease mutation	5332

SYNTHETIC Human INSULIN B CHAIN Protein

Referentie OPSA10541

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