Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.

Tauro-Obeticholic acid [863239-61-6]

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Referentie T13092-25mg

Formaat : 25mg

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Merk : TargetMol

Neem contact op met een lokale distributeur :

Telefoonnummer : +1 850 650 7790

Tauro-Obeticholic acid

Purity:99.82%

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COA HNMR HPLC

Tauro-Obeticholic acid

Catalog No. T13092Cas No. 863239-61-6

Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).

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Pack Size
1 mg
5 mg
10 mg
25 mg
50 mg
100 mg
1 mL x 10 mM (in DMSO)

Product Introduction

Bioactivity

Description	Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
In vitro	Obeticholic acid and taurine are conjugated in the liver to form taurine-obeticholic acid, which is secreted into the bile. Microorganisms in the ileum and colon can dissociate taurine-cholesteric acid and convert it into the parent drug, which can then be reabsorbed or excreted in feces.

Chemical Properties

Molecular Weight	527.76
Formula	C28H49NO6S
Cas No.	863239-61-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (94.74 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8948 mL	9.4740 mL	18.9480 mL	94.7400 mL
5 mM	0.3790 mL	1.8948 mL	3.7896 mL	18.9480 mL
10 mM	0.1895 mL	0.9474 mL	1.8948 mL	9.4740 mL
20 mM	0.0947 mL	0.4737 mL	0.9474 mL	4.7370 mL
50 mM	0.0379 mL	0.1895 mL	0.3790 mL	1.8948 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

microorganismsFXRcolonTauro-Obeticholic acidNR1H4TauroObeticholic acidinhibitileumInhibitorTauro Obeticholic acidmetabolite，liver