Telmisartan
Referentie M3289-100mg
Formaat : 100mg
Merk : AbMole Bioscience
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BIBR 277
Quality Control & Documentation
Biological Activity
Telmisartan (Micardis) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. In addition to blocking the Renin-Angiotensin System (RAS), telmisartan acts as a selective modulator of Peroxisome proliferator-activated receptor gamma (PPAR-γ), a central regulator of insulin and glucose metabolism. Telmisartan has binding affinity 3000 times greater for AT1 than AT2 receptors. Telmisartan also has the longest half life (24 hrs) of all angiotensin II type 1 receptor antagonists.
Chemical Information
| Molecular Weight | 514.62 |
| Formula | C33H30N4O2 |
| CAS Number | 144701-48-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Bianca N Loureno, et al. Efficacy of telmisartan for the treatment of persistent renal proteinuria in dogs: A double-masked, randomized clinical trial
[2] Xuan Jin, et al. Efficacy and safety of co-administered telmisartan/amlodipine and rosuvastatin in subjects with hypertension and dyslipidemia
[3] Rodolfo Pedro Rothlin, et al. Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19
[4] Jiagen Wen, et al. The influence of telmisartan on metformin pharmacokinetics and pharmacodynamics
[5] Yan Wang, et al. Telmisartan Improves Insulin Resistance: A Meta-Analysis